Azlocillin and cefonicid penetration into bone enhanced by probenecid
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چکیده
منابع مشابه
Aztreonam penetration into synovial fluid and bone.
Eighteen patients with uncomplicated degenerative joint disease requiring joint replacement (hip or knee) were given a single 2-g intravenous dose of aztreonam over a 5-min period preoperatively. The mean concentration in synovial fluid of 83.0 +/- 9.2 micrograms/ml averaged 0.99 times the concomitant levels in serum. The mean concentration in cancellous bone of 16.0 +/- 4.3 micrograms/g averag...
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Moxifloxacin is a fluoroquinolone with a broad spectrum of activity and good penetration into many tissues, including bone. Penetration of moxifloxacin into bone has not yet been studied using compartmental modeling techniques. Therefore, we determined the rate and extent of bone penetration by moxifloxacin and evaluated its pharmacodynamic profile in bone via Monte Carlo simulation. Twenty-fou...
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The penetration of cefonicid and cefazolin into cardiac tissue was compared after a single 30-mg/kg dose in 30 patients undergoing aortocoronary artery bypass graft surgery. Samples of the right atrial appendage, pericardial fluid, and serum were obtained at various times and assayed for drug content. The concentrations of cefonicid in serum and the atrial appendage were at least twice those ob...
متن کاملPenetration into bone and tissues of clindamycin phosphate PETER BAIRD
Clindamycin phosphate is an antibiotic which is effective against both Staphylococcus aureus and the anaerobic organisms. In thirteen patients, its concentration following joint replacement was measured by the agar diffusion method. In bone, the concentration was (mean + s.e. mean) 5.01 pg/ml ± 1.16, N=10; in capsule, 3.29 pg/ml ± 0*71, N=12; measured between 1.75 and 3.75 hr after intramuscula...
متن کاملPenetration into bone and tissues of clindamycin phosphate.
Clindamycin phosphate is an antibiotic which is effective against both Staphylococcus aureus and the anaerobic organisms. In thirteen patients, its concentration following joint replacement was measured by the agar diffusion method. In bone, the concentration was (mean +/- s.e. mean) 5.01 microgram/ml +/- 1.16, N=10; in capsule, 3.29 microgram/ml +/- 0.71, N=12; measured between 1.75 and 3.75 h...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1984
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.26.3.292